| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication of Biodegradable Hybrid Nanofibrous Sheet for Tissue Adhesion Barrier |
| 초록 |
Post-operative peritoneal adhesions are common and give serious complications for surgeons. They can cause patients pain, infertility, and potentially lethal bowel obstruction. This study was designed to evaluate the effect of hybrid nanofibrous sheet with nonsteroidal anti-inflammatory drug on the prevention of post-surgical tissue adhesion. For this goal, hybrid nanofibrous sheets composed of chitosan and PLGA were fabricated by electrospinning method. The hybrid Chitosan/PLGA nanofibrous sheet was characterized by several spectroscopic methods. Cell culture results showed that hybrid nanofibrous mat decreased initial cell attachment and proliferation. From in vivo animal test, it was observed that hybrid nanofibrous sheets were significantly effective in preventing post-operative adhesion and wound healing. |
| 저자 |
김선종1, 김원일2, 권오경3, 권오형1
|
| 소속 |
1금오공과대, 2(주)원바이오젠, 3칠곡경북대 |
| 키워드 |
Electrospinning; Nanofiber; Chitosan; Anti-adhesion barrier
|
| E-Mail |
|
