| 초록 |
The enhanced permeation and retention (EPR) effect is fundamental to nanomedicine for targeting the tumor. However, in several clinical trials, the results have shown that EPR effect is not sufficient to deliver nanomedicine. Herein, for enhanced EPR effect, we designed nano carrier for tumor-specific drug delivery. The prepared nano carrier was the copolymer of poly(ethylene glycol) and dextran derivatives and stable under aqueous conditions because of the amphiphilic structure. Our carrier can release nitric oxide (NO), known as a vasodilator in reductive conditions. Our nano carrier administered into tumor-bearing mice effectively enhances the tumor blood flow and permeability due to NO generation in tumor sites. Additionally, we tried to load the doxorubicin, which is an anti-cancer drug, and demonstrated that the dox-loaded nano carrier improved the therapeutic effect. Overall, NO generating nano carrier can be an EPR enhancer to deliver the anti-cancer drug more effectively. |
