| 초록 |
Inflammation plays an important role in the myocardialinfarction (MI) pathophysiology. Therefore, the modulation of macrophages ininflammatory response is crucial in MI treatment. Here, we synthesizedapoptotic fibroblast-derived nanovesicles conjugated with dextran and cardiachoming peptide (ApoNV-DCs). The ApoNV-DCs actively targeted ischemic myocardiumand were subsequently phagocytosed by macrophages in MI heart. Phagocytosed ApoNV-DCspolarized M1 macrophages to M2 macrophages, which resulted in the attenuationof inflammation and promotion of cardiac function recovery. Our approach maypave the way for an effective targeted delivery of nanovesicles to modulate macrophagesin inflammatory responses for cardiac repair. |
