| 초록 |
The aim of this study is to overcome solubility of poorly water soluble drugs, we prepared solid dispersion contianing nanoparticle of improvement of dissolution property nateglinide by using spray dryer. This solid disperions formulated to improvement of dissolution using AEA(polyvinylacetal diethylaminoacetate) as a water soluble for the solid dispersion using poloxamer as a surfactant. Characterization of nateglinide solid dispersion analyed by SEM, DSC, XRD and FT-IR. DSC and XRD were used to analye the amorphous of solid dispersions. FT-IR was used to analyze the salt formation by hydrogen bond between nateglinide and AEA. The in vitro release behavior of solid dispersion presented at simulated gastric juice(pH 1.2). The dissolution rate of nateglinide was dramatically higher than commercial drug(Fastic®). This studies displayed improvement of dissolution of prepared solid dispersion by using spray drying, poorly water soluble of nateglinide as orally pharmaceutical formulation. |
