| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effect of Physical Stimulation on Peripheral Nerve Regenerationwithin PCL/Pluronic F127 Nerve Guide Conduit |
| 초록 |
The sufficient functional recovery of damaged peripheral nerves has been considered as one of the clinical challenges. Artificial nerve guide conduits (NGC) to bridge the gap between severed nerve stumps are widely accepted as a useful alternative that creates a favorable environment for nerve regeneration. Recently, we developed a NGC with asymmetrical pore structure and hydrophilicity using polycaprolactone (PCL) and Pluronic F127. In this study, we applied ultrasound as a simple and non-invasive physical stimulus at the NGC-implanted site transcutaneously in rats for the enhanced nerve regeneration through the NGC. It was observed that the NGC-implanted group applied with the ultrasound had more rapid nerve regeneration behavior than the NGC-implanted group without any treatment. From the results, we could expect that the asymmetrically porous NGC/ultrasound system may be very helpful tool for sufficient peripheral nerve regeneration. |
| 저자 |
김진래1, 오세행1, 권구범2, 남궁욱2, 송규상3, 이진호1
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| 소속 |
1한남대, 2대전대, 3충남대 |
| 키워드 |
nerve guide conduits; ultrasound; nerve regeneration
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| E-Mail |
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