| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Neuronal cell membrane immobilized on neural interface devices for competent tissue integration |
| 초록 |
As a promising solution to this dilemma, we designed and fabricated titanium substrates covered with cell membranes extracted from differentiated PC12 cells to induce the surface adhesion of neural cell molecules, thus promoting neurite outgrowth and neural network formation on the surface. The modified substrates were prepared by pre-tethering of lipids on the surface of titanium and introducing extracted membrane components onto that as a membrane-like bilayer structure by vesicle fusion method. Successful surface modifications were confirmed via FT-IR, confocal laser scanning microscopy observation and fluorescence recovery after photo-bleaching (FRAP) assays. The coated interface showed significantly protect protein absorption. Furthermore, in vitro cell studies using microscopy and in situ fabricated mock neural sensors, revealed that the surface specifically encouraged adhesion and differentiation of neural cells when compared to astrocytes |
| 저자 |
Md Lemon Hasan, 김가을, Mahmoud A. Elnaggar, Goeen Jeong, 임충만, Myoung-Ryul Ok, 정윤기
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| 소속 |
한국과학기술(연) |
| 키워드 |
neural probe; cell membranes
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| E-Mail |
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