| 학회 |
한국공업화학회 |
| 학술대회 |
2008년 봄 (05/09 ~ 05/10, 한양대학교(안산)) |
| 권호 |
12권 1호 |
| 발표분야 |
화학공정 |
| 제목 |
THE PHASE TRANSFORMATION OF HYDRATE FORMS OF AN ACTIVE PHARMACEUTICAL INGREDIENT |
| 초록 |
The transformation from monohydrate to anhydrous form of an active pharmaceutical ingredient during crystallization was investigated. By simultaneously using the in-situ measurement: FBRM (Focused Beam Reflectance Measurement) and PVM (Paticle Video Microscope), the transformation from monohydrate to anhydrous form was determined in real time. Concurrently, these forms were identified by offline analysis technique: scanning electronic microscopy (SEM), crystallography (XRPD), thermal analysis (DSC, TGA). Water content or water content is the main factor determining the stability of anhydrous and monohydrate. The kinetic of phase transformation was found. |
| 저자 |
Nguyen Thi Nhat Phuong, 김광주
|
| 소속 |
한밭대 |
| 키워드 |
transformation; hydrate; in-situ measurement; crystallization
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| E-Mail |
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