| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 |
14권 2호, p.2640 |
| 발표분야 |
분리기술 |
| 제목 |
A Study on Phase Transformation Between Hyrate Forms of an Active Pharmaceutical Ingredient |
| 초록 |
The transformation of hydrates (hemipenta to mono) of an API during crystallization from the suspension of hemipenta hydrate solid in the saturated solution was monitored by simultaneously using the in-situ measurement of ultrasonic velocity and the offline analysis technique: optical microscopic, crystallography (XRPD). The function of ultrasonic velocity depended on concentration solid fraction in suspension was found. From calibration, thesolid composition, concentration of solution and supersaturation during the phase transformation and crystallization were estimated with elapsed time. As the result, kinetic of phase transformation and crystallization was found. The effect of mono hydrate seed, agitation rate and temperature on the phase transition as well as crystallization was also considered. |
| 저자 |
Nguyen Thi Nhat Phuong, 김광주
|
| 소속 |
한밭대 |
| 키워드 |
transformation; hydrate; ultrasonic; in-situ measurement
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| E-Mail |
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| 원문파일 |
초록 보기 |
