| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | Synthesis of 5-Amino-substituted 1,2,4-oxadiazoles from 5-alkoxy 1,2,4-oxadiazoles and aluminum amide reagent |
| 초록 | Oxadiazoles are having a large impact on multiple drug discovery programs across a variety of disease areas, including diabetes, obesity, inflammation,cancer, and infection. 5-Amino-substituted 1,2,4-oxadiazoles is effective as a treatment for prostate cancer. Generally, 1,2,4-oxadiazoles are synthesized from amidoximes with carboxylic acid derivatives or cycloaddition of nitrile oxides to nitriles. We synthesized of 1,2,4-oxadiazoles from azidoximes with using via Staudinger reaction followed by aza-Wittig reaction. In this work, 1,2,4-oxadiazoles were synthesized using smart cleavage reaction between 5-Amino-substituted 1,2,4-oxadiazoles and aluminum amide reagents, in good yields. |
| 저자 | Amarbayasgalan Nergui, 이상협 |
| 소속 | 대구가톨릭대 |
| 키워드 | Oxadiazoles; Aluminum amides reagent; |
