| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
The effect of cross-linker on reduction-responsive hydrogels derived from hyaluronic acid for drug delivery applications |
| 초록 |
In this work, novelreduction-responsive hydrogels were successfully prepared via inverse electron demand Diels-Alder reaction between hỷaluronic-norbornene and disulfide cross-linker with different length. Three kinds of cross-linker were synthesized by the esterification between different molecular weight of polyethylene glycol and disulfide tetrainze. The aim of this study is to report the effects of the length of the cross-linkers on hydrogels which may be controlled by the design of cross-linker. The results showed the properties of hydrogels such as swelling, mechanical properties, porous morphology, and drug release were affected by the length of cross-linker. The reduction-responsive hydrogels hold great potential as a biomaterial for stimuli responsive drug delivery applications. |
| 저자 |
주수빈, Trung Thang Vu, 조이준, 안병현, 이근대, 임권택
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| 소속 |
부경대 |
| 키워드 |
Diels-Alder reaction; reduction-responsive; Hydrogels; Cross-linker
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| E-Mail |
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