| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
생체활성 조직유도 고분자(의료용고분자부문위원회) |
| 제목 |
Reconstruction of a rabbit ulna bone defect using a PLA/β-TCP composite by a novel sintering method |
| 초록 |
Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polylactide (PLA)/b-tricalcium phosphate (b-TCP) composites with a novel sintering method. We prepared the composite by pressing and thermal treatment of the mixture of PLA, b-TCP after which we seeded bone marrow stromal cells (BMSCs) and either cultured them in vitro or subcutaneously implanted them into nude mice. The BMSCs more effectively formed bone-like structures on the PLA/b-TCP composites compared to PLA scaffolds. Also, we confirmed enhanced bone regeneration in the rabbit defect model using representative radiography and histological studies. This study revealed that generating osteoinductive PLA/b-TCP composites with novel sintering method could significantly enhance bone regeneration and be useful for bone tissue engineering. |
| 저자 |
정영미1, 박민성2, 이진우2, 김영하3, 김상헌1, 김수현1
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| 소속 |
1한국과학기술(연), 2연세대, 3광주과학기술원 |
| 키워드 |
PLA/TCP composites; bone marrow stromal cells; bone reconstruction; critical-sized ulnar bone defect
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| E-Mail |
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