| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Co-culture of NPCs and BMSCs on DBP /PLGA Scaffolds: in vitro |
| 초록 |
Nucleus Pulposus is jelly-like substance in the middle of the spinal disc. Bone marrow mesenchymal stem cells(BMSCs) are important progenitor and supporting cells that have the intrinsic ability to self-renewal and differentiate into multiple functional cells. In this study, we fabricated natural/synthetic hybrid PLGA scaffolds included 20% of DBP(DBP/ PLGA). Co-cultured nucleus pulposus cells(NPCs) with BMSCs were in the ratio 100:0, 75:25, 25:75, 0:100. Reverse transcription polymerase chain reaction (RT-PCR) was assessed to measure mRNA expression for type II Collagen, aggrecan and glycosaminoglycan(GAG) quantity from cells in scaffolds. We confirmed proliferation and differentiation of BMSCs to NPCs on DBP/ PLGA scaffolds. This research was supported by WCU(R31-20029) and MBC(0405-BO01-0204-0006) |
| 저자 |
김혜린, 송정은, 송이슬, 김형은, 안우영, 유한나, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
NPCs; BMSCs; DBP; PLGA; Scaffold.
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| E-Mail |
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