| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Effective Treatment of Osteomyelitis using Ion-Complexed Doxycline |
| 초록 |
Osteomyelitis is a bone infection by bacteria or fungus that causes severe bone damage. In recent years, antibiotic-loaded polymer matrix system has been frequently utilized to treat the osteomyelitis as a local delivery system. However, the insufficient release of antibiotics from the polymer matrix and secondary surgery to remove the polymer matrix still remained as critical limitations in clinical field. In this study, we developed ion-complexed doxycycline which can allow the sustained release of water-soluble antibiotic for sufficient period (~ 6 wks) without any additional polymeric matrix. The drug release behavior, cytotoxicity, and anti-bacterial effect of the ion-complexed doxycycline were investigated. Its remedial effect on the osteomyelitis was also evaluated by animal study using a rat model (femur osteomyelitis). This work was supported by the Korea Small and Medium Business Administration (2012-C0007124) and the NRF of Korea (2012R1A1A2041836). |
| 저자 |
오세행1, 남보라2, 이인수2, 송규상3, 이진호2
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| 소속 |
1단국대, 2한남대, 3충남대병원 병리학과 |
| 키워드 |
Osteomyelititis; Anti-biotic; Doxycycline; Sustained release
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| E-Mail |
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