| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 | 22권 2호, p.1829 |
| 발표분야 | 생물화공 |
| 제목 | Ultrathin electrodes-based single-cell technology for monitoring dopamine exocytosis |
| 초록 | Ultrathin Au nanowire (NW) electrodes-based single-cell system was developed for monitoring dopamine exocytosis. This system enables both an electrical cell stimulation and detection of the resulting neurotransmitter release with extremely high spatial resolution [1]. With highly precise and well-controlled electrode-to-cell interface, we observed that dopamine release from a PC12 cell is more stimulated by a more negative voltage pulse, which opens Ca2+ channels of the cell membrane for dopamine exocytosis. Detailed single-cell level studies of the biological responses to electrical stimulation could help us to understand such mechanisms and improve therapeutic efficacy. [This work was supported by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) of the Ministry of Science, ICT & Future Planning through the National Research Foundation of Korea.] Reference 1. M. Kang, S.M. Yoo, et al., Nanoscale. 8, 214 (2016). |
| 저자 | 유승민1, 강미정2, 김봉수2, 이상엽1 |
| 소속 | 1KAIST 생명화학공학과, 2KAIST 화학과 |
| 키워드 | 바이오칩/나노바이오공학 |
| 원문파일 | 초록 보기 |
