| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Tumor diagnosis with gadolinium - based nanoparticles |
| 초록 | Last several years, Gadolinium (Gd) - based contrast agent has been verified their ability as a T1 contrast agent. In addition, stem cells which have homing effects to tumor sites have been used for diagnosis and cure the tumor. However, Gd contrast agents have low cellular internalization, hydrophilic properties. In order to solve the limitations, we added photosensitizer (PS) to linear chelator conjugated Gd-based nanoparticles (PS-LCGN) through Photochemical internalization (PCI) to improve cellular internalization. Using this method, we entrapped the PS-LCGN into the human mesenchymal stem cells (hMSCs). Measuring the PS-LCGN with MRI scanner, PS-LCGN exhibited higher intensity than Gd - linear chelator. Under laser, PS damaged the cell membrane and enhanced internalization efficiency without side effects. In vivo test, using optical imaging and MRI scanner, we observed PS-LCGN enabled to detect the tumor. Consequently, PS-LCGN proved their potentials to use in tumor diagnosis |
| 저자 | 진민영, 김경섭, 박우람, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Gadolinium; contrast agent; Human mesenchymal stem cell; Photochemical internalization; photosensitizer; tumor diagnosis |
