| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.646 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | A Novel Polycaprolactone/Chitosan Scaffold for Bone Tissue Engineering |
| 초록 | Introduction The development of biocompatible materials which can be processed into three-dimensional scaffolds and design of appropriate configuration to enable the cellular infiltration and proliferation are one of the major issues in the tissue engineering. Polycaprolactone(PCL) is a well known hydrophobic biodegradable polymer and it is non-toxic aliphatic polyester with biocompatibility. The PCL has a potential as one of promising bone substitute materials because of its slow degradation properties and good biocompatibility. Chitosan is currently receiving a great deal of interest for medical and pharmaceutical application because of biodegradability, biocompatibility and suitable functional group for cell attachment, proliferation and differentiation. In this study, a novel PCL/chitosan scaffold was prepared for the for bone tissue engineering. Experimental PCL macromer was synthesized through the reaction of PCL diol with acryloyl chloride1. PCL macromer was confirmed using Fourier transform infrared and nuclear magnetic resonance spectrometer. Three-dimentional PCL networks were obtained by photopolymerization of PCL macromer. Thermal, mechanical, and morphological characteristics as well as degradability and biocompatibility of the PCL/chitosan hybrid matrices were investigated. The porosity of the PCL/chitosan was checked by scanning electron microscope. Proliferation of MG63 osteoblast cell in the PCL/chitosan scaffold was checked in vitro. Results and discussion From FTIR and NMR results, the terminal hydroxyl groups in the PCL diol were subsequently converted to acrylate groups by the reaction with acryloyl chloride. From degradation test in vitro, commercial PCL(Mw=80.000) degraded very slowly but PCL networks showed a faster degradation kinetics than PCL itself. Reference 1. Kwon H.Y., Yoo M.K., Park I.K., Kim T.H., Lee H.C., Lee H.S., Oh J.S., Akaike T., Cho C.S., Biomaterials, 24, 801-808(2003). |
| 저자 | 송호현, 유미경, 조종수 |
| 소속 | 서울대 |
| 키워드 | polycaprolactone; chitosan; scaffold; tissue engineering |
