| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.285 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Polycaprolactone/Hydroxyapatite Composite Scaffolds for Bone Tissue Engineering |
| 초록 |
Autograft and allograft, ceramics, natural and biodegradable synthetic polymers have been used as bone substitutes for bone defect. Hydroxyapatite (HA), which is a typical bone replacement for a long time since the material mimics the natural bone mineral, has good osteoconductive properties and poor fabrication properties. Polycaprolactone (PCL) is well known hydrophobic biodegradable polymers, which is non-toxic aliphatic polyester with biocompatibility. PCL has a potential as promising bone substitutive materials because of its slow degradation properties. However, the mechanical strength of PCL is too weak to use for bone tissue engineering. Therefore, to increase the mechanical and osteoconductive properties of PCL, PCL/HA composite scaffolds were prepared by photopolymerization of the PCL macromer in the presence of HA. The compressive mechanical strength and morphology of PCL/HA composite scaffolds were examined. The cell toxicity and morphology of osteoblast were observed to evaluated the possibility for bone substitutes. |
| 저자 |
권해용1, 이현철*2, 김석영**3, 이광길4, 조종수***
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| 소속 |
1농업과학기술원 잠사곤충부, 2*전남대, 3**영남대, 4***서울대 |
| 키워드 |
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| E-Mail |
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