| 초록 |
Novel injectable poly(β-amino ester)-poly(ε-caprolactone)-poly(ethyleneglycol)-poly(ε-caprolactone)-poly (β-amino ester)(PAE-PCL-PEG-PCL-PAE) pH/temperature-sensitive hydrogels were prepared and applied to peptide and protein delivery. Hydrogels showing a sol-gel transition with changing temperature or/and pH have been proposed for use as injectable drug delivery systems. Here, we report a tailored novel injectable polymeric material of which aqueous solutions undergo sol-gel transition by pH change, as well as by temperature change. Furthermore, this hydrogel has positive charges, and it can form ionic complexes with negatively charged drugs such as protein and peptide. As a result, the drug loading into the matrix is both by mechanical absorption and by ionic interaction. And thus the drug release could be controlled. |
