| 초록 |
Various nanomaterials can absorb near infared light and effectively emit heat to kill cancer cells as promising photothermal agents. However, the utilization of conjugated polymers for photothermal theraphy has been limited because of difficulty in preparing dispersions in aqueous media. We prepared water-dispersed nanoparticles of poly[2,1,3-benzothiadiazole-4,7-diyl[4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b:3,4-b']dithiophene-2,6-diyl]] (PCPDTBT) by forming phase-separated thin films of PCPDTBT and a phospholipid, followed by the conventional lipid vesicle preparation process. The diameters of resulting nanoparticles were 130nm in average. The nanoparticles could be successfully uptaken into HeLa cells and the efficient photothermal ablation of the cancer cells was confirmed. Acknowledgments: This work was funded by the Korea Research Foundation (2012-047716) and the Ministry for Health and Welfare (A10301712131330200). |
