| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Depending on the Amount of PLGA/DBP/SIS Hybrid Scaffold for Inflammatory Reaction |
| 초록 |
Abstract: Because demineralized bone particle (DBP) contains various bioactive molecules such as cytokines, it is widely used biomaterials in the field of tissue engineering. Porcine small intestinal submucosa (SIS) derived from the submucosal layer of porcine intestine, both generate a minimal inflammatory response following implantation and have been approved by FDA for many types of biomedical application. In this study, PLGA/20% DBP/0, 10, 20, 40 and 80% of SIS scaffolds were evaluated using an NIH3T3 cells were seeded into PLGA/DBP/SIS scaffolds. After 1, 2 and 3days of cell proliferation and viability were measured by MTT assay. The morphology of cellular adhesion were observed by scanning electron microscope (SEM). We found that PLGA/DBP/SIS blend films implanted into a rat showed significantly diminished inflammatory responses. |
| 저자 |
김아람, 이유정, 심초록, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
NIH3T3; PLGA/DBP/SIS scaffold; inflammatory; cytokines
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| E-Mail |
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