| 초록 |
Poly(lactic-co-glycolic acid) (PLGA) as a biocompatible material is approved by FDA. However, PLGA is not a desirable polymer for fast release of small water soluble molecules owing to its long degradability during 30days. So, we can adjust the release rate of POX because the degradable rate of POX is faster than PLGA. We prepared Polyoxalate loaded PLGA films from various preparation ratios for film physicochemical, biological characteristic, physics chemical properties such as thickness measurement, surface morphology, transparency and DSC, Contact angle, XRD, FT-IR, SEM were carried out. Biological properties like proliferation and mRNA expression were conducted to evaluate possible of POX/PLGA film. Though these results, we concluded POX can be improve PLGA film’s characteristic and POX/PLGA film can be applied to diverse tissue engineering application. This research was supported by NRF-2012M3A9C6050204 and the Brain Korea 21 PLUS Project, NRF. |
