| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Attachment and Proliferation of Rabbit Corneal Endothelial Cells on Vanillin/PLGA Film |
| 초록 |
The corneal endothelial cells (CECs) are single layer of cells on the inner surface of the cornea and maintains the cornea in the slightly dehydrated state that is required for optical transparency. Vanillin is one of major components of vanilla, a commonly used flavoring agent and preservative and is known to exert potent antioxidant and anti-inflammatory activities. Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. In this study, we performed MTT, SEM, fluorescence staining, ELISA, RT-PCR, and FACS. We confirmed the adhesion and the proliferation of rabbit CECs on vanillin/PLGA. The increased hydrophilic surface of the vanillin/PLGA films accounts for their more cell-biomaterials interactions and higher cell attachment than the PLGA film. These results demonstrated that vanillin/PLGA films provide suitable surface for CECs. This research was supported by WCU (R31-20029). |
| 저자 |
김경희, 이지혜, 김슬지, 김영래, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Vanillin; PLGA; Corneal endothelial cells
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| E-Mail |
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