| 학회 |
한국공업화학회 |
| 학술대회 |
2010년 가을 (10/27 ~ 10/29, 대전컨벤션센터) |
| 권호 |
14권 2호 |
| 발표분야 |
차세대 스텐트 소재 |
| 제목 |
Formation of PLGA-aspirin microsphere particles by supercritical fluid extraction of emulsion and its application |
| 초록 |
Delayed release of anti-inflammatory drug is very important in withdrawing of a restenosis process, In this study, we want to produce homogeneous PLGA-aspirin microsphere particles by supercritical fluid extraction of emulsion. Our strategy for slow release is this PLGA-aspirin microsphere as a nucleus of releasing spot in PLA medium. Dissolving of outer PLA medium expose PLGA-aspirin microsphere into PBS solution. Release rate of aspirin was decided by the difference of dissolving rate between PLA and PLGA in an aqueous solution. It suggests that two biocompatible dissolving polymers will be adequate for slowly drug-releasing matrix in aqueous solution. |
| 저자 |
구재환, 황현수, 이수진, 오성화, 김귀철
|
| 소속 |
전남나노바이오연구센터 |
| 키워드 |
supercritical fluid; PLGA; microsphere; emulsion
|
| E-Mail |
|
