| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
조직공학용 다공성 고분자 지지체 |
| 제목 |
Effect of Diblock Copolymer on the Fabrication of 3D Scaffods by Thermally Induced Phase Separation Method |
| 초록 |
Biodegradable and biocompatible synthetic polymers have been widely utilized as three-dimensional(3D) scaffolds. In this study, a regular and highly interconnected macroporous poly(L-lactic acid)(PLLA) scaffold was fabricated from a PLLA-dioxane-water ternary system with added poly(ethylene glycol)(PEG)-PLLA diblock using thermally induced phase separation(TIPS). The morphology of the scaffold was investigated TIPS parameters. The phase diagram was assessed visually on the basis of the turbidity. The addition of diblock series(0.5wt% in solution) stabilized interconnections of pores at a later stage without segregation or sedimentation. The pore size of the scaffold could be easily controlled in the range 50-300mm. A macroporous PLLA scaffold was used to study a hard-tissue cell transplantation, MC3T3-E1 cell culture. The cells successfully proliferated in the PLLA scaffold in the presence of added PEG-PLLA diblock for 4 weeks. |
| 저자 |
이두성 |
| 소속 |
성균관대 |
| 키워드 |
Scaffold; TIPS; cell culture
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| E-Mail |
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