| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
생체활성 조직유도 고분자(의료용고분자부문위원회) |
| 제목 |
Honeycomb-mimic PLLA scaffold for tissue engineering |
| 초록 |
A scaffold is a dreamed biomaterial of tissue engineers which can culture cells three-dimensionally outgrowing the two-dimensional cell culture in a petri dish to repair or regenerate tissues and organs. Various scaffolds mimicking natural extracellular matrix have been developed to make an optimum environment for cell adhesion, growth, migration and differentiation from macro- to nano-levels. In this study, a biodegradable honeycomb-mimic scaffold, which consists of nano-fibers, was fabricated to mimic a hierarchical architecture of real tissues. A method of the directional phase-separation was achieved by freezing a mold from bottom to top ways. The novel method was applied to fabricate tubular pores in the honeycomb-mimic scaffold. This novel method overcame the limit of a present solid-liquid phase-separation method which pore shapes in the scaffold are decided by shape of porogens and solvent crystals. The fabricated honeycomb-mimic scaffold showed a hierarchical architecture from nano- to macro-scale. The hierarchical structure of honeycomb-mimic PLLA scaffold shows good cell adhesion and differentiation due to the surface roughness in the scaffold and collagen-mimic nano fibers influencing gene expression. |
| 저자 |
Young Gun Ko1, Laura A. Smith2, Peter X. Ma3
|
| 소속 |
1Department of Biologic and Materials Sciences, 2Univ. of Michigan, 3Department of Biomedical Engineering |
| 키워드 |
ㅁㅁㅁ |
| E-Mail |
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