| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
Korea-Australia Joint Symposium: Functional Macromolecules for Advanced Applications (English) |
| 제목 |
Brain-on-a-Chip Technology for Mimicking Brain Microvasculature Physiology and Pathology |
| 초록 |
We present a brain-on-a-chip platform in which multiple types of human brain-originated brain cells were cocultured in a 3D microenvironment with perfusable brain microvasculature. The brain microvasculature was fabricated by using microneedles as templates. By seeding the brain microvascular endothelial cells in the luminal surface of the channel and embedding other neural cells in the collagen, a 3D brain model was prepared. The brain microvasculature physiology was confirmed through transendothelial permeability, immunofluorescence imaging, and cytokine assay. Neuropathology such as brain tumor and particulate matter-induced neuroinflammation were recapitulated in the brain-on-a-chip platform. Pathophysiological features as well as the efficacy of pharmaceutical candidates were evaluated in the platforms. |
| 저자 |
김홍남 |
| 소속 |
한국과학기술(연) |
| 키워드 |
Brain-on-a-chip; Biomimicry; Physiology; Pathology
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| E-Mail |
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