| 초록 |
Here, we present an analysisof nanoscale deformation of PDMS molds in response to heat and pressure duringthe repetitive molding process of thermoplastic polymers. The width and heightof the nanoridges of PDMS molds decreased as the number of replications ofthermoplastic polymers increased. Using the precisely controlled deformation ofnanostructures in PDMS molds, we demonstrated that nanostructures of differentsizes can be fabricated on representative thermoplastic and UV-curable polymers.Using the precisely tunable methodologies of nanostructures, we propose amethodology to fabricate hierarchical multiscale scaffolds with controlledhydrophilic and hydrophobic properties by employing capillary force lithographyin combination with oxygen plasma modification. In response to multiscalenanotopographic and chemically modified surface cues, the O-FMN patch enhancedregeneration of the mineralized fibrocartilage tissue of the tendon–boneinterface and the calvarial bone tissue. |
