| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표) |
| 제목 |
Sustained-Release of Therapeutic Proteins from Multilayer Films Assembled on the Sidewalls of Nanoporous Templates |
| 초록 |
Drug release systems based on the layer-by-layer (LbL) assembled multilayer films have recently received much attention due to their ability to easily incorporate biomolecules within the thin film geometry and to release the assembled biomolecules through film degradation. However, in many cases, such multilayer films are immediately degraded with the release of active agents incorporated from the very early stage, resulting in the initial burst release or the very short drug release period. In the present study, in order to overcome such limitations, nanoporous substrates were employed as substrates for the LbL deposition, instead of conventionally used flat substrates. By varying the pore size of nanoporous templates used, we were able to modulate the release kinetics of model proteins, allowing the release of biomolecules in more sustained manner with the suppression of initial burst release in the early stage due to the phenomena termed as the “hindered” diffusion. |
| 저자 |
조용현1, 홍진기2, Paula T. Hammond3, 차국헌4
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| 소속 |
1서울대, 2지능형유도조합체연구단, 3에너지환경 화학융합기술전공, 4경희대 |
| 키워드 |
layer-by-layer; controlled release; protein release; porous substrate(s); biodegradable
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| E-Mail |
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