| 초록 |
Paclitaxel (PTX) has been used as an effective antitumor agent for the treatment of carcinomas including breast, lung, and ovarian cancer. However, the solubility of PTX limits uses of the drug. Oil and methanol mixture was used to improve its solubility in most cases, but they also bring side effects. Herein PEGylated HAS(HAS-PEG) was used for a fabrication of HAS nanoparticles which contains PTX. The HAS-PEG/PTX can be readily self-assembled with film casting and re-hydration. And the PEGylation of HAS would increase the solubility of the protein at the same time. The results suggest that the nanoparticles can be used as a platform with various hydrophobic drugs, which will reduce the formulation-mediated toxicity. |
