| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
biodegradable fibers incorporated with Phase change material(PCM) and indocyanine green for NIR light-triggered and localized anti-cancer drug release |
| 초록 |
This study introduces a new system for NIR light-triggered, localized release of drugs. The system consists of biodegradable poly(ε-caprolactone) (PCL)-based fibers having a core loaded with doxorubicin (DOX) and a sheath incorporated with indocyanine green (ICG) as a NIR-absorbing agent together with a biocompatible/degradable, phase-changeable fatty acid. Upon NIR irradiation, the photothermal agent will generate heat to raise the local temperature of the fibers. When the temperature is above the melting point of the fatty acid, nano-pores will be generated in the fibers. This response to NIR irradiation allows the instant release of DOX from the fibers through the pores, leading to the significant enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent. |
| 저자 |
박주향1, 손진호1, 최지현1, 김다인1, 서호준2, 강동국3, 현동춘1
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| 소속 |
1경북대, 2한국생산기술원, 3평화 오일씰 |
| 키워드 |
biodegradable polymer; phase change material(PCM); NIR; cancer therapy
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| E-Mail |
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