| 초록 |
pH/redox responsive fluorescent carbon dots loaded with photothermal molecules-IR825 (FNP(IR825)) was synthesized for controlling photothermal cancer therapy via fluorescence “off-on” behavior. A disulfide-crosslinking polymer was carbonized to make carbon dot, then IR825 was loaded to create FNP(IR825) as fluorescence OFF state. When FNP (IR825) is internalized into tumor cells, disulfide bonds are cleaved due to the GSH, recovering fluorescent ON. In addition, this platform offers anticancer properties by the release of IR825 from FNP. Furthermore, in vitro and in vivo studies have shown that FNP (IR825) performed excellent biocompatibility with high cellular uptake and can effectively kill treated tumor cells when exposed to NIR illumination. This system showed high sensitivity to cancer environment and induces the release of PTT-mediated cytotoxicity via fluorescent on-off behavior. This work was supported by Korea National University of Transportation in 2018. |
