| 초록 |
Recent progress on plasmonic biosensors has enabled LSPR-shift assay with single nanoparticles. Single-nanoparticle plasmonic sensors are particularly attractive because of small sample volume required, better signal-to-noise resolution, and lower limits of detection. However, variations in the corresponding LSPR-shifts to surrounding refractive index change (∆n) among structurally different particles have not fully studied. Hence, we discuss the LSPR scattering peak wavelength distribution of individual gold nanoparticles, the effect of this variation to the sensitivity of LSPR-based sensors, and methods to minimize the variations in the LSPR responses among different particles. This promising plasmonic biomolecular assay on the nanoarray should find application in parallel screening of nucleic acid and protein profiles and will compete with current microarrays. Finally, most recent development on a plasmonic dimer that utilizes plasmonic coupling will be also discussed. |
