| 학회 |
한국재료학회 |
| 학술대회 |
2012년 가을 (11/07 ~ 11/09, 라카이샌드파인 리조트) |
| 권호 |
18권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Biocompatibility evaluation of Platelet-rich plasma (PRP) with hyaluronic acid/gelatin-BCP hydrogel loading in BCP sponge scaffold for bone regeneration |
| 초록 |
Platelet-Rich-Plasma (PRP) has been widely used in clinical bone regeneration and bone wound healing. Bio-ceramics are comparable to the mineral component of natural bone and showed good osteoconductivity. In this study, 10% Biphasic Calcium Phosphate (BCP) mixed hyaluronic acid-gelatin hydrogel with PRP (HGB10/PRP), and these hydrogel was loaded in BCP sponge scaffold (HGB10) to improve mechanical property and biocompatibility. In vitro studies of BCP, HGB10 and HGB10/PRP scaffolds were evaluated by cytotoxicity, cell attachment and proliferation studies using MC3T3-E1 preosteoblast cells. In vivo studies were investigated with autologous PRP (HGB10/PRP) of rats for 2 weeks, 4 weeks and 8 weeks compared with BCP, HGB10 scaffolds. HGB10 scaffold was higher mechanical property than BCP scaffold. In in-vitro studies, cell count, cell proliferation behavior and live cell of HGB10/PRP scaffold were evaluated higher than without PRP scaffold. There results showed that with HGB10/PRP scaffold had biocompatibility and osteo-inductive properties for the treatment of bone defect. |
| 저자 |
So-Ra Son1, Nguyen-Thuy Ba Linh2, Dong-woo Jang3, Hun-Mo Yang1, Young-Ki Min2, Byong-Taek Lee3
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| 소속 |
1Department of Biomedical Engineering and Materials, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Hyaluronic acid; Gelatin; BCP; Platelet-rich plasma; Bone
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| E-Mail |
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