| 초록 |
Nano-particle (NP) is a small object in nanometer scale that behaves as a whole unit in terms of its physico-chemical properties. Physico-chemical properties of NPs, including size, surface charge are key factors for their in vivo administration. We present surface modification of pluronic-based nano-carriers (NC) that were prepared by single phase photo-crosslinking without using an organic dispersion phase. Amine functionalization was achieved by incorporating cysteamine and chitosan was achieved by incorporating acrylated water soluble chiotsan into NC. NIR-dye functionalization was done by reacting NHS-cy5.5 with amine-functionalized NC. The surface charge and the thermo-sensitive size variations were characterized by using DLS. Acknowledgement: This research was partially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (R15-2008-006-02002-0). |
