| 초록 |
Poly(ethylene imine)(PEI) and (phenylthio)acetic acid(PTA) can self-assemble in the water phase. These nanospheres are sensitive to temperature. In the range of 20℃~50℃, with 4 kinds of phenolic acids(PAs)(Cinnamic acid(CA), hydroxy cinnamic acid(HCA), dihydroxy cinnamic acid(DCA), methoxy hydroxy cinnamic acid(MHCA)), the phase transition temperature changed significantly. The higher the PAs concentration, the lower the phase transition temperature, which meaned that the nanospheres became unstable. It was because PAs also had carboxyl groups, it may had electrostatic interaction between themselves and the amino groups of PEI. The PEI/PTA/PA conjugate showed circular shape from TEM. The release profile at different temperature was measured. Only in PEI/PTA, the release and the temperature effect was small. When CA was added, the release was relatively increased. With HCA and DCA, the release rate increased significantly. MHCA showed some effect on release, but was small. |
