| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Iridium Complex Encapsulated in Redox-Responsive Hyperbranched Polyglycerol Nanogel for Minimally Invasive Photodynamic Therapy |
| 초록 |
Ir(III) complexes have attracted much attentions in biological approach due to their outstanding advantages in generation efficiency of reactive oxygen species, luminescence lifetime and photo-stability. However, the use of Ir(III) complexes as therapeutic agent has been limited because of their high cytotoxicity and lack of cancer selectivity. Herein, we synthesized iridium complexes encapsulated in self-cross-linked nanogels(IrNG) by thiol-disulfide intermolecular exchanges. High drug loading capacity of over 20% was provided through hydrophobic interaction with polymer nanogel and lots of vacancies in hyperbranched polymer. Size and GSH-responsiveness of IrNG was suitable for targeted cancer therapy. Also, higher cell viability in dark was confirmed, but cytotoxicity of IrNG were maintained under light irradiation. Therefore, these data suggest photo- and GSH-responsive cancer therapy of IrNG with reduced side-effect caused by undesired distribution of iridium complexes. |
| 저자 |
이채규1, 이채헌1, 이준희1, 김병수2, 권태혁1
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| 소속 |
1울산과학기술원, 2연세대 |
| 키워드 |
Photodynamic therapy; Drug delivery system; Iridium complex; Nanogel; Disulfide-thiol exchange; GSH responsive degradation
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| E-Mail |
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