| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Intracellular targeting delivery of anticancer drug with AB2 miktoarm polymeric carrier |
| 초록 |
The delivery of drugs to the intracellular target organelles such as nucleus and mitochondria is a promising and efficient strategy for getting higher therapeutic efficacy with minimizing side effects. We have designed and synthesized a bioreducible AB2 miktoarm polymer that can form self-assembled nanoparticles (NPs) in aqueous solution and has functional groups available for chemical conjugation with an anticancer drug. For targeting the mitochondria which is known as “power house of cells”, triphenylphosphorinum (TPP) molecule was physically or chemically introduced into the doxorubicin (DOX) conjugated AB2 miktoarm NPs. The nanoparticle size (200-250 nm in diameter) of the DOX conjugated AB2 miktoarm polymer was reduced to 100-150 nm after loading of lipophilic TPP. The DOX and TPP contents in NPs was characterized by 1H-NMR and UV Vis. The DOX conjugated NPs with the chemically or physically introduced TPP were evaluated in terms of intracellular targeting and anticancer effect. |
| 저자 |
허강무1, 강한창2, 이은지1, 이용규3, Li Li1, 이영주1, 누런나비엠디1
|
| 소속 |
1충남대, 2가톨릭대, 3한국교통대 |
| 키워드 |
miktoarm polymer; intra cellular targeting anticancer; doxorubicin
|
| E-Mail |
|
