| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Heparin-based biomolecular nanoparticles for targeted cancer therapy |
| 초록 |
In this study, we have attained dramatic in vitro tumor shrinkage and tumor vasculature disruption using a ternary biomolecular nanoparticle comprised of polymeric carrier polysaccharide heparin, anticancer drug retinoic acid and targeting ligand folic acid. The folic acid linked heparin-retinoic acid conjugates (HFR) have been successfully synthesized and characterized by FT-IR, 1H-NMR, DLS, and TEM measurements. The HFR conjugates could self-assemble in aqueous media to form nano-aggregates and their antitumoral effect were evaluated in vitro and in vivo. |
| 저자 |
오인혁1, 박일규1, 김유진2, 허강무1, 이용규2
|
| 소속 |
1충남대, 2충주대 |
| 키워드 |
heparin; retinoic acid; nanoparticle; folic acid; drug delivery
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| E-Mail |
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