| 초록 |
Vesicles have attracted significant attention in therapeutic delivery, bioreactors, artificial cells as well as organelles due to their aqueous core and a molecular bilayer shell structure, which resembles the natural biological membrane. This allows effective encapsulation and isolation of biomolecules such as proteins, exosomes, metabolites, and nucleic acids from the surrounding biological environment. In this work, we present a microfluidic strategy for producing polymersomes, vesicles with self-assembled polymer bilayer structure, and exploit their utility in spatiotemporal isolation and retrieval of extracellular vesicles. Moreover, we systematically investigate the effect of polymer composition, solvent, osmotic pressure, and interfacial tension during preparation on long-term stability of these vesicles. |
