| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Sustained Release Formulation of Aceclofenac as Polyoxalate Microspheres : Effect of Preparation Condition on Release Behavior |
| 초록 |
Aceclofenac(AF) inhibits the cyclooxygenase has anti-inflammatory activity by inhibiting prostaglandin synthesis. AF has short biological half-life and dosing frequency of more than one per day. Therefore, the aim of this study is to control the release of ND through the microspheres. In this study, the microspheres were prepared using a POX. POX is biocompatible, biodegradable polymer and half-life is 7~10days. As an experimental model of drug delivery, microspheres were prepared using emulsion-solvent evaporation method (O/W) by using different preparation condition. The prepared microspheres is analyzed by SEM, FT-IR, XRD and DSC. In vitro release test of AF was experimented in PBS(7.4). These results showd that the release behaviors can be effectively controlled by the preparation conditions. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
이천중, 김영래, 김혜윤, 이선의, 조성준, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Microsphere; Aceclofenac; Polyoxalate(POX); In vitro release; O/W emulsion-solvent evaporation method
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| E-Mail |
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