| 초록 |
Folic acid conjugated SiO2/TiO2 hollow nanoparticles (FA-HNP) with 50 nm were fabricated using dissolution and re-deposition method. Furthermore, the protoporphyrin IX (PpIX) is encapsulated in FA-HNP (FA-HNP-PpIX) and act as a photosensitizer for photodynamic therapy (PDT) of cancer. The FA-HNP-PpIX exhibited high loading efficiency of PpIX, and is able to generate cytotoxic singlet oxygen under visible light excitation for photodynamic therapy (PDT). In order to confirm the targeting effects of FA, two human breast cancer cell lines, MCF-7 (folate receptor positive) and SK-BR-3 (folate receptor negative), are used as experimental and control cell line. When MCF-7 cells are treated with FA-HNP-PpIX and irradiated, the viability is decreased to 25.5 %, which is ca. 3.33 times higher PDT efficiency than that of other PpIX based experiment. Judging from these data, FA-HNP-PpIX is very suitable for PDT application, and can be expanded to practical applications with further studies. |
