| 초록 |
We present the synthesis of pyrene-modified chitosan (Py-CS) nanogels through the hydrophobic interactions and excimer formation of pyrene anchors in aqueous solutions. Tannic acid (TA) was further added to the Py-CS solution as a colloidal stability-enhancing additive by noncovalent secondary interactions such as π-π stacking and hydrogen bonding, which can be observed with fluorescence and FT-IR spectroscopy. Subsequently, solution viscosity of the resulting nanogels was analyzed to evaluate the nanoscale behavior of the modified polysaccharides. Also, TA reported as a substance that prevents tumor cell growth is evaluated to have a high anticancer effect if combined with cisplatin, an inorganic anticancer agent, especially in liver cancer cells. In this study, chitosan-based nanogels adsorbed with cisplatin-tannic acid complex (Py-CS/TA-PtII) are proposed as drug delivery systems with enhanced anticancer effects. |
