| 초록 |
Mucoadhesive polymers are effective for a site-specific drug delivery onto digestive system. For enhancement of the mucoadhesion, mucin-interacting functional moieties, thiol groups, are introduced; however, the covalent modification requires harsh chemical reaction. Lately, catechol/pyrogallol-containing adhesives have been spotlighted as good hemostatic and tissue adhesives, but their in vivo mucoadhesive properties have not been demonstrated. Herein, we found mucoadhesion properties of tannic acid (TA), which formed medicinal glues by hydrogen bonds with poly(ethylene glycol) (PEG), called TAPE. It remained on esophageal mucus layers at least for 30 minutes and subsequently in stomach even after 8 hours of oral feeding. The mucoadhesion is originated from the interactions between catechol/pyrogallol of TA and mucin, exhibiting pH dependency; it strongly adheres to mucin in neutral condition. Thus, TAPE might be useful as long-lasting esophageal mucoadhesive composites. |
