| 초록 |
Atopic dermatitis (AD) is a common chronic inflammatory disease of the skin. It is associated with high level of reactive oxygen species (ROS). When the accumulation of excessive ROS over time exceeds the power of intrinsic antioxidant defense system in the body, the resulting high oxidative stress plays a role in the pathogenesis of AD. Here, we propose antioxidant hydrogel patch that can scavenge excessive ROS from the AD lesion. The ROS-scavenging catalytic nanoparticles were homogeneously embedded in the biocompatible hydrogel. The hydrogels showed an efficient removal of ROS and exhibited no cytotoxicity with fibroblasts. Furthermore, it showed cytoprotective effects in ROS-containing media. When the patches were applied to the AD-induced mouse models, the skin was significantly recovered and several AD-related biomarkers were decreased. Our finding represents that the continuous removal of ROS from the skin in AD by hydrogel patch could be potentially applicable to treat AD. |
