| 초록 |
PET-MRI contrast agents have been studied that coat the surface of nanoparticles with radioisotopes using chelators. However, the metal ions bonded to the chelators are partially dissociated. So, the radioisotope and the metal magnetic material can be separated. In this study, the radioactive isotope 64Cu is bound to iron oxide nanoparticles for the synthesis of RMNP (radioactive magnetic nanoparticles). The surface of nanoparticles is coated with SiO2 to reduce the toxicity of the metal, and the nanoparticles are synthesized with a core-shell structure. Physicochemical properties of RMNP are confirmed FT-IR, XRD, DLS, SEM, TEM, EDS, SQUID and MRI. Also, PET-MRI images of RMNP were acquired to evaluate the performance of nanoparticles and demonstrate the potential of contrast agent development. |
