| 학회 |
한국화학공학회 |
| 학술대회 |
2012년 가을 (10/24 ~ 10/26, 부산 BEXCO) |
| 권호 |
18권 2호, p.1911 |
| 발표분야 |
생물화공 |
| 제목 |
Reconstruction and in silico analysis of genome-scale metabolic model of Ralstonia eutropha H16 |
| 초록 |
Ralstonia eutropha H16 is a lithoautotrophic Gram-negative bacterium using CO2 and H2 as main sources of carbon and energy without any organic substrates. It is known for polyhydroxyalkanoates (PHAs) producer and is an environmentally promising bacterium because of its capability of degradation of aromatic compounds. Systems metabolic engineering to improve its metabolic performance is applied here to make R. eutropha H16 a more efficient and robust biofactory. Here, a genome-scale model called RehMBEL1391 composed of 1391 reactions 1171 metabolites was constructed. Constraints-based flux analyses were performed to refine and validate the genome-scale metabolic model under environmental and genetic perturbations. [This work was supported by the Technology Development Program to Solve Climate Changes (systems metabolic engineering for biorefineries) (NRF-2012-C1AAA001-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center of Global Frontier Project (2011-0031963) from the Ministry of Education, Science and Technology (MEST)] |
| 저자 |
김동인, 박종명, 김태용, 이상엽
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| 소속 |
한국과학기술원 |
| 키워드 |
genome-scale metabolic model; Ralstonia eutropha H16; in silico analysis
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| E-Mail |
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| 원문파일 |
초록 보기 |
