| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Cloaking Protein Shield Zr-MOF Delivery Platform for Targeted Nanomedicine |
| 초록 |
In this study, we intended to advance the possibilities of a Zr-MOF-based delivery platform by utilizing self-assembling bonds between the MOF active site and various carboxyl groups in functional shield proteins. Functional cloaking proteins such as GST-Afb (HER2 and EGFR) are very stable, inhibit reactions with other proteins and can be used for targeting. Such proteins can stabilize the active site of the MOF and also act as a targeting moiety. We effectively controlled the MOF surface via an intrinsic reaction between the active site and recombinant proteins to develop a targeted drug delivery platform. This study provides an insight into the potential applications of Zr-MOFs in nanomedicine and the future of the biointerface of MOFs. |
| 저자 |
오준용1, 유자형2
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| 소속 |
1울산과학기술원, 2울산과학기술원 자연과학부 |
| 키워드 |
protein corona; target drug delivery; recombinant protein; mof
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| E-Mail |
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