| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Effect of SIS/Silk Composite Film for Corneal Endothelial Cells Regeneration: In Vitro Study |
| 초록 |
Silk has been studied as the scaffold for tissue engineering due to their excellent biodegradability and biocompatibility. In addition, SF film has high transparency and less immune response in vivo. However, SF film shows hydrophilicity of surface. In order to overcome it, this study used SIS. SIS is collagen-based ECM and provides environment for cells. So SIS was incorporated into the silk to improve interaction of cell-supportor. We hypothesized that SIS/Silk composite may provide a proper environment to CEnCs. We fabricated water delivered SIS/SF film. Physical properties and biological properties were carried out. These results show that SIS has positivity effected on attachment, proliferation and marker expression of CEnCs. We demonstrated SIS/Silk composite may offer a good environment and optimistic for regeneration of corneal endothelial cells and has possibility for application. This research was supported by the Brain Korea 21 PLUS and NRF-2012M3A9C6050204. |
| 저자 |
김은영1, 강길선1, 차세롬1, 김산나1, 송정은1, 주천기2
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| 소속 |
1전북대, 2가톨릭대 |
| 키워드 |
SIS; Corneal endothelial cells. silk aqueous solution
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| E-Mail |
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