| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Release Behavior and Antitumer Efficiency of Etiposide Loaded Triblock Copolymeric Miceller Nanoparticles |
| 초록 |
To estimate the feasibility of polymer as a drug carrier, amphiphilic triblock copolymers, poly(p-dioxanone-co-L-lactide)-block- poly(ethylene glycol) nanoparticles were prepared in aqueous medium using acetonitrile as a solvent by nano-precipitation technique. From the observation of atomic force microscopy (AFM) the nanoparticles exhibited a uniform, smooth and spherical shape of around 45 nm diameters. Further, dynamic light scattering (DLS) measurement showed a uni-modal size distribution of around 100 nm hydrodynamic diameter. The preliminary results in lung cancer (NCI-H-182 cell line), showed a significant reduction of cell number while the cells were incubated with Etiposide -loaded nanoparticles. Acknowledgement This work was supported by the Regional Research Centers Program of the Korean Ministry of Education & Human Resources Development through the center for Healthcare Technology Development. |
| 저자 |
Shanta Raj, Remant Bahadur K.C., 황평한, 김학용
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| 소속 |
전북대 |
| 키워드 |
nanoparticle; triblock copolymer; drug release
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| E-Mail |
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