| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 | 14권 1호, p.534 |
| 발표분야 | 생물화공 |
| 제목 | Combined transcriptome and proteome analyses of adaptive response to alkylating agents in Escherichia coli |
| 초록 | Alkylation damage to DNA occurs when cells encounter alkylating agents in the environment or generate active alkylators in metabolic pathways. In Escherichia coli, adaptive response system, mainly controlled by Ada protein, activates DNA repair system in response to alkylation damages. In this study, we compared the adaptive response of E. coli wild-type and ada mutant strains using the integrated transcriptome and proteome analyses to elucidate the regulatory and physiological characteristics of the adaptive response. We also examined Ada-dependent induction of the adaptive responses genes and fine tuning of individual gene expression according to the growth phase for extended periods of exposure time to a methylating agent. [This work was supported by the Korean Systems Biology Research Program from the Ministry of Science and Technology. Further supports by LG Chem Chair Professorship and Center for Ultramicrochemical Process Systems (Korea Science and Engineering Foundation) are appreciated.] |
| 저자 | 이상엽1, 백종환2, 한미정2 |
| 소속 | 1KAIST 생명화학공학과 / KAIST 바이오및뇌공학과, 2KAIST 생명화학공학과 |
| 키워드 | adaptive response; transcriptome; proteome; Escherichia coli |
| 원문파일 | 초록 보기 |
